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Reaction: Homocysteine + Methylcobalamin Methionine + Tetrahydrofolate Importance: Methionine synthase plays a critical role in maintaining methionine levels for protein synthesis and SAM synthesis

Vorsicht ist angebracht bei schweren Nieren- oder Lebererkrankungen, aktiver Chemotherapie, Immunsuppression, Schwangerschaft, Stillzeit und komplexer Medikation

isolation window of 1 m/z

125,126,127,128,129,130,131 To date, two RNAi therapeutics, ONPATTRO and GIVLAARI, have been approved for commercial application, and two siRNAs, lumasiran (ALN-GO1) and inclisiran, have been submitted for new drug application (NDA) to the FDA