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However, if memory CD8 + T cells originate from the progenitors that are refractory to self-inflicted damage with low levels of Sb9 and GzmB, rather than from fully differentiated CTLs, Sb9 is not required for the development and survival of these subsets of memory CD8 + T cells (81)

2.2 Preclinical and clinical applications Resveratrol has demonstrated multifaceted antitumor potential across breast, colorectal, and hematologic malignancies through preclinical studies, though clinical translation remains challenging due to pharmacokinetic limitations and insufficient high-quality clinical validation

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