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Knowler WC, Barrett-Connor E, Fowler SE, et al

89 Additionally, the binding affinity between protein disulfide-isomerase (P4HB) and prostaglandin G/H synthase 2 (PTGS2) is enhanced by lactylation of P4HB at K311, subsequently leading to SH3-domain-containing GRB2-like protein B1 (SH3GLB1)-mediated mtROS accumulation and coiled-coil domain-containing protein 2 (NDP52)-induced mitophagy

Aside from SCFAs, a recent body of research emphasizes the significance of tryptophan-derived indoles, which influence neuroimmune balance via AhR activation, resulting in tighter BBB control and less peripheral-to-central inflammatory communication [145]

Yang H, Zhang C, Yang M, Liu J, Zhang Y, Liu D, Zhang X: Variations of plasma oxidative stress levels in male patients with chronic schizophrenia