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2018 and Foyer 2020)

Front Neuroendocrinol (2010) 31(4):40019

Over the past twenty years, the incidence of gout has nearly doubled, likely connected to an increase in obesity in the general population

Activation of cerebral endothelial cells (CECs) by Th1 cytokines changes occludin and vascular endothelial cadherin (VE-Cadherin) phenotypes in TJs and AJs of CEC via several inflammatory genes [66]