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NNMT as Target (Kraus et al., 2014): NNMT knockdown in white adipose tissue and liver protected against diet-induced obesity by increasing cellular energy expenditure

Of these seven groups, the Firmicutes , Proteobacteria , and Verrucomicrobia phyla demonstrated a significant main effect of treatment group on relative abundance after BenjaminiHochberg correction for multiple comparisons, while Bacteroidetes and Actinobacteria demonstrated significant main effects of treatment group on relative abundance before BenjaminiHochberg correction

Effects were additive with exercise, suggesting distinct molecular mechanisms (PMID: 38969654) Important Considerations# Critical warning : 5-Amino-1MQ is a preclinical research compound