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c , Representative bright field images of Huh7 and H1299 cells from vehicle and combo treatment (SU056: 1 M, BAY876: 1 M) groups with or without 2DG (5 mM) treatment (72 h)

The -secretase enzymes are generally believed to reside at the plasma membrane, although some studies have suggested that a pool of -secretase may also exist at the trans -Golgi network (TGN) (Sisodia, 1992