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However, in a recently completed multicenter, phase III randomized controlled trial (NCT04072822), the results have shown that compared with Anakinra combined with zinc treatment, the prednisone treatment group showed higher survival and lower incidence of acute kidney injury at 90 days in severe alcoholic hepatitis (SAH) ( Current studies have demonstrated that oxidative stress and proinflammatory environment in hepatocytes activate apoptosis signal-regulating kinase 1 (ASK1), exacerbating liver inflammation, apoptosis and fibrosis (Polyzos et al., 2020)

Barrett T, Wilhite SE, Ledoux P, Evangelista C, Kim IF, Tomashevsky M, et al

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Randomized double-blind trial of treatment of vitiligo: efficacy of psoralen-uv-a therapy vs narrowband-uv-B therapy