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NOTE: The FDA banned the sale of ephedra herbal supplements containing measurable levels of ephedrine in 2004 due to an increased risk of stroke, myocardial infarction and sudden death (see ma-huang_ephedra)

The most reliable non-laboratory indicator is reduced effectiveness, weaker appetite suppression or slower results despite consistent dosing

The most-wanted comparison simply has not been run

(Heme iron, found in meat, fish, and poultry, appears to be absorbed intact.) Ascorbic acid, by maintaining iron in the ferrous state, can enhance the absorption of oral iron, however, the magnitude of this increase is in the range of 10% and only occurs with doses of ascorbic acid, vitamin C of 500 mg or greater