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AAVs, notably AAV2, are less immunogenic, non-pathogenic, and particularly effective in transfecting RGCs (276278)

10.1007/s00384-022-04224-5 6

Endocr Rev 1984

For example, the VP1 H248P mutation alters the surface charge of the VP1 HI loop, inducing conformational changes in the BC and HI loops (Supplementary Fig