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3A1) (Supplementary 4 sheet 1)

Yes, Vitamin B deficiency can happen, mainly in those with restrictive diets or certain health issues

Experiments using isotope-labeled extracellular proteins show that when supplied with extracellular serum albumin, Ras-transformed cells, which rely on glutamine metabolism to support growth, utilize macropinocytosis to maintain proliferation under glutamine-limiting conditions 120