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To identify the proteins and pathways modulated by the combination treatments versus the single treatments, we applied a linear regression model to the matched global proteomic and phosphoproteomic data ( Figure 7 )

3.6 Anti-muscular atrophy Muscular atrophy is characterized by disrupted molecular pathways such as non-physiological Hedgehog (Hh) signaling, dysfunctional AKT signaling and dysregulation of ubiquitin-proteasome to overall cellular protein turnover, resulting in upregulated components of the ubiquitin-proteasome pathway, specifically muscle atrophy F-box (MAFbx/atrogin-1) and muscle ring finger 1, that promote proteolytic degradation

Typical Dose: 200400 mg/day

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