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We also wanted to deliver the drug through the skin instead of through an IV. When mixed, positively charged peptides and negatively charged heparin bind to create a nanogranular paste that can be injected under the skin, forming a cache of material that is then diffused in the circulatory system and travels to blood clots when they appear

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In comparison, in the first rat ID study, the best improvement in permeation of the 1 mg/kg SEQ ID NO: 3 peptide dose was only about 5 fold (up to 0.15%), which was achieved with 50 mg/kg sodium caprate (Table 5 )

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