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Drugs acting on the monoaminergic and opioid systems, such as bupropion-naltrexone and bupropion-zonisamide, are also being studied

LH peaked at ~5 hours and returned to pre-trigger by 12-14 hours Trial Context Hypothalamic amenorrhea (chronic SC, twice weekly) Dose Studied 6.4 nmol/kg Route Subcutaneous, twice weekly Source/Notes Reduced response over time consistent with desensitization Trial Context HSDD modulation (women, men) Dose Studied 1 nmol/kg/h IV infusion Route Intravenous, 75-minute infusion Source/Notes Imperial College / Hammersmith trials, 2021-2023 These are trial protocols, not dosing recommendations

doi: 10.1016/S0140-6736(23)02750-2

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