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4.2 Gene therapy delivery The evolution of smart hydrogels in the field of gene therapy has progressed from simple nucleic acid protection and delivery toward advanced integrated functions such as organelle targeting, gene-protein co-delivery, and self-powered therapeutic systems

Ferroptosis is regulated by glutathione peroxidase 4 (GPX4), a lipid repair enzyme (14,15), and is associated with the following group of genes: Iron responsive element binding protein 2, citrate synthase, ribosomal protein L8 and ATP synthase, H+ transporting, mitochondrial Fo complex subunit C3 (subunit 9) (2)

10.1007/978-3-319-28383-8_14 [DOI] [PubMed] 190.Grabska-Kobyecka I, Szpakowski P, Krl A, Ksiek-Winiarek D, Kobyecki A, Gbiski A, et al

As menopause approaches, these symptoms can progressively worsen