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While these findings suggest potential utility for early detection and risk stratification, multicenter validation and longitudinal follow-up are needed to confirm that alterations in carnitine levels precede eGFR decline and are not merely a consequence of impaired renal clearance

(2018) showed that the pathophysiology of hepatic IR injury is primarily marked by lipid metabolic reprogramming, which results in a secondary effect of inflammation, thereby highlighting the role of lipid metabolism in disease pathogenesis

Lagrost L, Persgol L, Lallemant C, Gambert P