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Experimental GA treatment in vitro resulted in enhanced expression of inducible NO synthase (iNOS) and DUSP4 and inhibition of COX-2 expression

Both are extremely thiophilic metals and bind to sulfur containing metabolites and cysteine-rich proteins, often with toxic results

So, a possible limitation of restoring the cytoplasmic redox state in aged cells may be the facilitation of tumor development from decreased cellular senescence