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As reported in Table 1, among the analyzed tumor types, CRC shows the highest number of preclinical studies on DNA methylation ( N = 24), including 16 diagnostic and eight prognostic studies

Human fibroblasts with mutations in COL5A1 and COL3A1 genes do not organize collagens and fibronectin in the extracellular matrix, down-regulate alpha2beta1 integrin, and recruit alphavbeta3 instead of alpha5beta1 integrin