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doi: 10.1186/s12943-020-01247-w 271 AmouzegarAChelvanambiMFildermanJNStorkusWJLukeJJ

10.3390/ijms18040852 Int

In Bca cells treated with brusatol, CHAC1 expression significantly rises, leading to GSH depletion, ROS buildup, and increased lipid peroxidation, which are key features of ferroptosis

First, while antibiotic suppression is used to invoke a role for gut microbiota in the generation of the metabolite(s) monitored, antibiotics can also have direct effects on the host, altering normal metabolism (57, 58)