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Furthermore, induction of HO-1 in SLE confers an anti-inflammatory phenotype to monocytes and DCs, while myeloid cells in these patients show downregulated HO-1 levels, suggesting that its deregulation is involved in disease progression (90)

The GSH binding motif of GPx1 is comprised of four arginine (Arg or R) and one lysine (Lys or K) residues surrounding the Sec of catalytic tetrad [8, 17, 18]