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Nausea alone isnt an emergency, but severe or worsening symptoms warrant dose adjustment or further evaluation

Concluding remarks Initial mechanistic hypotheses concerning the molecular bases of opioid tolerance focused on homologous desensitization, viewing internalization as a key protective step for maintaining analgesic efficacy

To determine whether the improved PK properties of the QMP-engineered fusions would translate into enhanced efficacy, we repeated the GTT in human FcRn Tg32 mice