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Omega-3 Fatty Acids When you hear Omega-3 fatty acids, many people think of cardiovascular health

The pathophysiology of depression involves modifications to multiple pathways, such as the hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis, dysregulation of the oxidant/antioxidant system balance, increased levels of inflammatory cytokines, leptin resistance, altered plasma glucose, insulin resistance, neuronal brain-derived neurotrophic factor (BDNF) reduction, and decreased serotonergic neurotransmission in different brain regions (27)

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Cadmium (Cd) is a common heavy metal contaminant that has been demonstrated to cause organ damage through the activation of inflammatory processes, oxidative stress, mitochondrial damage, and cell death, which ultimately leads to neurotoxicity, gastrointestinal damage, renal damage, and reproductive damage [124, 125]