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We explore new methods that enhance the protective role of mucus through physical reinforcement, pathogen neutralization, muco-trapping and rehydration, as well as strategies that overcome the mucus barrier to improve drug delivery, including physical modulation, mucoadhesive design, muco-penetrating design, mucolytics and active targeting

Beyond platform-specific readiness, broader translational constraints determine whether TME-guided designs can become part of routine cancer care

Statistical analysis Statistical analysis of the quantified data was performed by analysis of variance (ANOVA)

We identify a conserved metabolic crosstalk between the Met/SAM cycle and the choline oxidation pathway