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Nikolsky sign is manifested by a dermal-epidermal cleavage when applying tangential pressure to apparently intact skin, even this sign was not pathognomonic but also helpful to diagnose this condition

The coefficient of determination ( R 2 ) and the significance of the relationship between variables was indicated by probability levels

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Therefore, the binding affinities and stability of crocin with AKT1 and TP53, while promising, need to be validated through experimental studies