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140 Aspirin has also been shown to induce non-apoptotic cell death in human melanoma cells by disrupting the mitochondrial network and increasing mitochondrial Ca + levels and reactive oxygen species (ROS)

R Glutathione conjugation: GSTs catalyze the conjugation of the thiol group of reduced glutathione (gamma-Glu-Cys-Gly) to an electrophilic carbon, nitrogen, or sulfur atom on the substrate

These findings highlight salidroside as both a standalone antioxidant and a sensitizer that boosts the reparative potency of MSCs in POI treatment

For clarity, their components are labeled: E 1p , E 1o and E 1b (EC 1.2.4.4)