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Long-term administration of berberine increases the expression of IL-1 and inducible nitric oxide synthase (iNOS) in Alzheimers disease mice hippocampus, and ameliorate memory impairment (Zhu and Qian, 2006)

As ebselen is already an FDA-approved drug, its repurposing as a radioprotective drug may be easier compared to any other new synthetic drug substance

doi: 10.1007/s12035-015-9604-5

Tests carried out on mice in order to determine LD50 as well as with the purpose of obtaining data about acute, sub chronic and chronic toxicity have been unsuccessful as this peptide applied intravenously or intraperitoneally in a broad dose range from 10 ng to 100 mg/kg of body weight, did not induce any toxic changes