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Recent studies highlight how GPx4, in particular, reduces complex hydroperoxides using glutathione as a reducing agent, underscoring its importance in lipid metabolism

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Peroxiredoxin 6 (PRDX6), microsomal glutathione S-transferase 2 (MGST2), and gamma glutamyl transferase 5 (GGT5), which contribute to glutathione-dependent leukotriene synthesis [39, 40] and may promote vasoconstriction in diving mammals [41], were also present in seal cluster 3 (Table 1)

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