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SLU-PP-332 works at the nuclear-receptor level through ERR / /

[21] In a study of Korean women, mercury was the single heavy metal driving ten-year cardiovascular risk within a mixture that also included lead and cadmium, and postmenopausal women needed far less exposure to reach that risk than women who were still cycling: elevated risk appeared at roughly the 20th percentile of exposure in postmenopausal women, compared to the 55th percentile in premenopausal women

318 In addition, the appropriate timing of drug administration is critical, particularly in patient stratification and drug delivery

Only a better definition of the relevant molecular check points will clarify the mechanisms that underlie these opposite functional outcomes and will identify promising targets for therapeutic interventions