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Dezotti 2017

Genetic polymorphisms in the methylenetetrahydrofolate reductase gene ( MTHFR ) and risk of vitiligo in Han Chinese populations: a genotype-phenotype correlation study

A more realistic goal for HbS in patients receiving routine replacement transfusions who have a history of stroke, intolerance to hydroxyurea, or who have had a negative reaction to it is 25% to prevent an increase in HbS of more than 30% after four weeks if the patient does not receive replacement transfusions [5]