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Description

Several of these chaperones are colocalized or associated with the PD related proteins, E3-ubiquitin ligase (E 6.3.2.19), parkin, -synuclein and the dopamine transporter (DAT) [119]

Further in vitro and in vivo experiments uncovered metformins ability to suppress oxidative stress by promoting the expression of Nuclear factor erythroid 2-related factor 2 (Nrf2)

It is worth mentioning that although rotenone-induced PD models have been widely used in PD studies, there almost no cases of rotenone-induced PD in humans