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48 Furthermore, different subsets of macrophages present distinct metabolic functions

Concurrently, depression affects approximately 300 million people globally, with years lived with disability accounting for 37.3% of all mental disorders, rendering it a leading cause of disability (GBD 2019 Mental Disorders Collaborators, 2022)

Some of these are stable, and can diffuse through cell membrane affecting membrane functions, such as lipidlipid interactions, ion gradients, fluidity and permeability, thus, causing a major issue for cell homeostasis (Skouta et al., 2014