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Some have proposed that ammonia is converted to glutamine, which causes cerebral edema either directly by its osmotic effect 37,38 or indirectly by decreasing other osmolytes, thereby promoting water retention

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The association of APR-246 with induction of ferroptosis (either by pharmacological compounds, or genetic inactivation of SLC7A11 or GPX4) had a synergistic effect on the promotion of cell death, both in vivo and ex vivo