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BTZ-induced ER stress suppresses the expression of key myelination-associated genes, including P0 and Krox20, in SCs, thereby disrupting their physiological functions and contributing to the demyelination of peripheral nerve fibers (Shin et al., 2010)

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The apparent volume of distribution at steady state is large relative to body water volume, indicating substantial distribution into peripheral tissues

The findings indicated that AST/Bex treatment restrained transcription and activity of the amyloidogenic enzyme BACE1, consequently decreasing A oligomers as well as 80-kDa intracellular APP/A species