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More recently, a combination of SoC and immunotherapy has been explored in clinical trials, resulting in a transient delay of tumor relapse for a few months 6

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4 A decade of progress: novel antifungal drugs targeting resistance The main mechanism of antifungal action lies in inhibiting essential molecules, such as ergosterol (azole class) or 1,3--D-glucan (echinocandins), or by binding to ergosterol (polyene class), leading to the formation of pores and altering the integrity and permeability of the cell membrane, thereby affecting the membrane or fungal cell wall

J Biol Chem 2013;288:29069-80