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Efficacy and safety of the probiotic Lactobacillus paracasei LP-33 in allergic rhinitis: a double-blind, randomized, placebo-controlled trial (GA2LEN Study)

Thereafter, other microbial-derived factors such as the endotoxin lipopolysaccharide (LPS) 49 , as well as mediators of inflammation, such as the cytokines interleukin (IL)-1 and tumor necrosis factor (TNF)-, prostaglandins (PGs), growth hormone-releasing hormone (GHRH), and growth factors, were recognized as sleep-regulating factors 50

Neurobiol Aging 33:499509

Presently, ongoing clinical trials are investigating the focused inhibition of complement as a pharmacological intervention, and the results of these studies will contribute to the development of personalized treatment strategies for patients