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Indeed, chronic psychological and emotional stress leads to activation of the hypothalamic-pituitary-adrenal (HPA) axis, which increases the production of cortisol [56, 57]

Among them, drug-carrier delivery into the brain assisted by FUS-induced BBB opening, could be a promising approach to address this unmet need because of its site-specificity, noninvasiveness, and applicability to a wide range of therapeutics