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While deletion of FXR from Apoe / mice enhanced atherosclerosis (442), it remains unknown if the anti-fibrotic effects of FXR in stellate cells is conserved in plaque associated vSMCs

An ALS and FTD-associated mutation in p62 (also known as SQSTM1), the first of these receptors to be described, compromises selective autophagy of ubiquitinated proteins 64