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Why is that so important

Both ME and IDH have NAD+ dependent counterparts that only reside in the mitochondria and generate the NADH needed for electron transport chain activity

Salmaso et al., 2014

some studies report up to 530 mg/100g DW in wild specimens 4 King Oyster (Pleurotus eryngii) ~170180 mg Highest in fresh-weight rankings per some sources