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for instance, glycine and serine are glutamine-derived and are important suppliers of the folate cycle from one-carbon metabolism (as reviewed by The enzymes involved in both cysteine catabolism and anabolism, CBS and CSE, are frequently associated with malignancy and more aggressive cancer phenotypes (124, 127, 142147), suggesting that at least one of the two pathways are relevant in cancer, and they might be working simultaneously as a way to keep on moving the metabolic cellular network