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There is also discussion in the same Medical News Today article that standard trials escalate doses monthly mainly to optimize effect under defined trial conditions, but that in real-world practice, individuals differ widely in sensitivity, metabolism, side effect profile, etc

Maintenance dose (week 5 onward): 1mg (1000mcg) tesamorelin + 200300mcg ipamorelin, adjusted based on IGF-1 response measured via serum blood work at week 6 and week 12