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Introduction -thalassemia is the most common inherited disease, characterized by decreased or absent -globin chain synthesis and hemoglobin A production ( The incidence of myocardial iron overload in transfusion-dependent -thalassemia patients has increased from 11.4%15.1% in early studies to 26.1%36.7% in recent studies ( As iron loading progresses, the capacity of transferrin to bind and detoxify iron is eventually exceeded, leading to non-transferrin-bound iron in plasma, which promotes oxidative stress, mitochondrial dysfunction, and ferroptosis ( Mechanisms of myocardial injury caused by iron overload Studies have shown that iron myocardial overload causes myocardial dysfunction

This qualitative difference suggests the glucagon component contributes something beyond simple appetite suppression, potentially shifting fundamental metabolic set points

Le CIRS (Chronic Inflammatory Response Syndrome) est un syndrome d'inflammation chronique lie aux biotoxines (moisissures, Lyme)

Therefore, it is not surprising that cardiomyocytes have a high volume of mitochondria (30-40% of the entire cell) [54]