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At this stage, we say the patient has overt or clinical hypothyroidism There is some debate as to the benefit of treating those with sub-clinical hypothyroidism in symptomatic patients with a high TSH, but normal T4 a trial of treatment may be suitable Hypothyroidism is typically treated with a daily dose of thyroxine 1.6 g/kg lean body weight daily

The free fraction available for receptor binding will be lower than the nominal total concentration

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