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Description

Designing nanoformulation for the nose-to-brain delivery in Parkinsons disease: advancements and barrier

M.MamaevaV.SahlgrenC.Rivero-MllerA

doi: 10.1177/08853282221076708

Abbreviations BD: Bipolar disorder ATP: Adenosine triphosphate CNS: Central nervous system UA: Uric acid NFAT: Nuclear factor of activated T cells GSK-3: Glycogen synthase kinase 3 MDD: Major depressive disorder CSF: Cerebrospinal fluid NMDA: N-methyl-d-aspartate ROS: Reactive oxygen species NAA: N-acetyl-aspartate BDNF: Brain-derived neurotrophic factor RBC: Red blood cell CVD: Cardiovascular disease NO: Nitric oxide TBARS: Thio barbituric acid reactive substances LPO: Lipid peroxidase SOD: Superoxide dismutase ER: Endoplasmic reticulum GWAS: Genome-wide association study MAM: Mitochondria-associated-membrane UPR: Unfolded protein response SNP: Single nucleotide polymorphism ANK3: Ankyrin-3 DISC1: Disrupted-in-schizophrenia 1 NADH: Nicotinamide adenine dinucleotide DHEA: Dehydroepiandrosterone PCP: Phencyclidine VPA: Valproic acid ASC: Apoptosis-associated speck-like protein PAMP: Pathogen-associated molecular patterns DAMP: Danger-associated molecular patterns BHB: Beta-hydroxybutyrate BMI: Body mass index BBB: Bloodbrain barrier MBL: Mannan binding lectin MHC: Major histocompatibility complex PET: Positron emission tomography NAC: N-acetylcysteine BCAA: Branched-chain amino acid Omega-3: Omega-3 polyunsaturated fatty acid KYN: Kynurenine TRP: Tryptophan IDO: Indoleamine-pyrrole 2,3-dioxygenase TDO: Tryptophan dioxygenase KynA: Kynurenic acid QA: Quinolinic acid 3HK: 3-Hydroxykynurenine T2DM: Type-2 diabetes mellitus LPS: Liposaccharide AhR: Aryl hydrocarbon receptor ECT: Electroconvulsive therapy COX: Cyclooxygenase inhibitor SCN: Suprachiasmatic nucleus CCG: Central Clock genes NAS: N-acetylserotonin SP: Seasonal patterning HPA: Hypothalamicpituitaryadrenal axis CRH: Corticotropin-releasing hormone VTA: Ventral tegmental area SH: Serotonergic hallucinogens References Andrejew R, Oliveira-Giacomelli , Ribeiro DE, et al