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Also, constant or prolonged cisplatin treatment often results in the acquisition of resistance through the selection bias of alternative cell survival pathways, leading to therapeutic failure and poor prognosis [9, 10]

Pharmacological inhibitors such as MCC950, which inhibit NLRP3 ATPase activity [50] and CY-09 which prevents its activation, and Bay-11 7082 which targets NF-B and offers therapeutic options [51]