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Gentiopicroside, a secoiridoid glycoside from gentiana rigescens franch, extends the lifespan of yeast via inducing mitophagy and antioxidative stress

Br J Pharmacol (2016) 173(23):3292306

Through the combined suppression of priming signals and inhibition of activation cues, Nrf2 limits NLRP3 assembly, caspase 1 activation and maturation of IL-1 beta and IL-18 [68]

However, the level of preventive effectiveness was higher in rats given ORES treatment, as evidenced by the renal parenchymas better organized histological characteristics and high proportion of apparent intact tubular segments