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Ser/gly pathway metabolites are required for RT recovery in NSCLC To validate the observations in the plasma of patients with NSCLC and confirm our hypothesis of augmented ser/gly pathway dependency, we performed 13 C 6 -glucose tracing and metabolomics analysis in a panel of 5 NSCLC cell lines, i.e., NCI-H1299, NCI-H125, NCI-H1975, Calu-6 and NCI-H520 to identify the RT related metabolic changes

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For a full list, our panels cover 30+ cytokines influenced by homocysteine (e.g., IL-1, TNF-, IFN-) and 100+ genes/rsIDs from methylation to redox pathways

These findings support the hypothesis that pyroptosis may be involved in melanocyte death associated with ROS in vitiligo [12, 60]