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171 In recent years, a 5-LOX inhibitor upstream of LTB4 has been under development for bronchial asthma, but current 5-LOX inhibitors have problems such as lack of selectivity, structureactivity relationships, methaemoglobin formation, and poor efficiency and oral availability

These include the bell-shaped dose-response curve, central effects after peripheral administration, a delayed and prolonged time course, and some penetration of the blood-brain barrier in essentially intact form

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ordering mitochondria-targeted compounds and their SS-31 has been exceptional in our lab models