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Nature 365: 185188 Winter J, Klappa P, Freedman RB, Lilie H, Rudolph R (2002) Catalytic activity and chaperone function of human proteindisulfide isomerase are required for the efficient refolding of proinsulin

The breakdown products are then transported out of the cell and further metabolized, either through acetylation to form mercapturic acids, catalyzed by N-acetyltransferases, or through carbonsulfur bond breakage mediated by cysteine-S-conjugate -lyase

Multifunctional combination platforms, capitalizing on high loading capacities, permit co-delivery of PROTACs with chemotherapeutics, epigenetic modifiers, or immunomodulators, thereby overcoming resistance through synergistic multitarget engagement [295]

De este modo, se estimula el funcionamiento cerebral , mejorando la concentracin y la memoria a corto y largo plazo