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accordingly, renal function is the principal determinant of systemic drug concentrations and, consequently, inner-ear drug accumulation ( Environmental factors, including NICU ambient noise levels, may potentiate ototoxicity through the activity-dependent MET channel uptake mechanism described in the Cellular Entry section above

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Indeed, Jin and colleagues (2010[20]) reported an increase in catalase activity in the liver of zebrafish after 14 days of exposure to Atrazine at a concentration of 1000 g/L