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The individual BAs were chosen based upon prior reports of CA, GCA and TCA as potential biomarkers of liver injury in clinical and nonclinical studies (Tribe et al

Camurus CEO Fredrik Tiberg said his company will work with its external manufacturer and with the FDA to bring CAM2029 to patients living with acromegaly as soon as possible, and noted that Camurus has already held labelling discussions with the FDA

utilized 4-phenylbutyrate (a potential PFIC2 treatment) in BSEP-deficient hepatocyte-like cells and found that the level of BSEP expression and the calculated biliary excretion index were preserved

Nature 579:409414