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TXNRD1 levels were noticeably lower in responders in the anti-CTLA4-treated YTN16 mouse model

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a study in rats of a single-tablet combination demonstrated that including methionine could minimize liver toxicity (measured by serum ALT and AST) at therapeutic (100 mg/kg) and highly toxic (1000 mg/kg) acetaminophen doses (Iyanda 2010)

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